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基因组序列比对是生物信息学的核心技术之一，其目标是通过比较不同物种或个体的DNA序列，揭示进化关系、功能区域或突变位点。随着高通量测序技术的普及，数据量呈指数级增长，传统比对算法面临效率与精度的双重挑战。优化算法成为提升科研效率的关键，以下从多个角度探讨其核心优化方向。

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